Fabry Disease Treatment Market Size, Share Global Analysis Report, , 2020 – 2026

Industry Insights

[195+ Pages Report] As per the market research report published by Facts and Factors, the global Fabry disease treatment market was valued at approximately USD 1.77 billion in 2019 and is expected to generate revenue of around USD 3.78 billion by end of 2026, growing at a CAGR of around 9.83% between 2020 and 2026.

Market Overview       

Fabry disease is an X-linked lysosomal storage condition. The deficiency of the alpha-galactosidase enzyme in a patient causes progressive organ dysfunction. The development of Fabry diseases is primarily caused by an abnormal accumulation of a particular fatty matter known as globotriaosylceramide. The skin, heart, eyes, brain, kidneys, central nervous system, and gastrointestinal system are all affected by this irregular accumulation.

Industry Growth Factors

The treatment's main goal is to reduce and alleviate the patients' crippling discomfort while also preventing disease progression. Fabry's disease cannot be cured, but the harm it causes can be reduced with proper treatment. In the year 2003, the FDA approved the intravenous administration of Agalsidase as an enzyme replacement therapy (ERT) for the treatment of Fabry's disease. Before that, patients were given carbamazepine and diphenylhydantoin to relieve pain, and their estimated lifespan was between 40 and 50 years. The use of new treatments such as substrate replacement therapy and chaperone treatment has risen rapidly in recent years. However, enzyme replacement therapy has long been the most popular treatment, with a large market share that is expected to sustain during the forecast period. The market is growing as the number of patients suffering from Fabry disease is increasing. Aside from that, broad R&D activities and the potential approval and launches of promising pipeline products such as substrate decline treatments and compound replacement treatments are expected to boost the industry's growth over the forecast period. In addition, the market is expected to expand due to the legalization of oral chaperone therapy in developing countries and the advancement of gene therapy. Additionally, due to patent expirations, the proliferation of biosimilars is expected to increase during the forecast era. Patients with Fabry disease often experience strokes, excruciating pain, an early heart condition, impaired kidney function, which may contribute to kidney failure, and debilitating gastrointestinal symptoms. Since there is no cure for Fabry disease, care focuses on managing complications associated with disease progression and providing symptomatic relief. Various patients are often misdiagnosed due to mild symptoms. The global Fabry disease market is expected to expand at a significant pace in the coming years as a result of these factors.

Segmentation Analysis

The global Fabry disease treatment Market is segregated into drugs, route of administration, treatment, and regions.  The drug category is segmented into migalastat, agalsidase beta, and pipeline drugs. The pipeline drugs are expected to hold highest market share in 2019. Based on treatment, the market has been categorized into substrate reduction therapy, chaperone treatment, enzyme replacement therapy, and others. Both Shire's Replagal, and Sanofi's Fabrazyme have received European approval, only Fabrazyme has received approval in the United States. Current clinical trials are focusing on improving the safety and efficacy profile of ERTs, as well as the development of innovative oral therapies that can replace intravenous infusions. The segment's dominance is supported by strong sales of Fabrazyme and Replagal, as well as the possible acceptance of successful pipeline candidates. However, the introduction of new, more effective treatment methods, such as gene therapy, is critical for a significant improvement in patient benefits. In terms of route of administration, the market has been segregated into oral, and intravenous.

Regional Analysis

Due to various expanding human service use and developing infrastructure, Asia Pacific offers major growth opportunities for pharmaceutical companies. Because of the large populations in emerging countries, the region is expected to grow the fastest in the coming years, followed by Latin America. In 2018, North America surpassed Europe as the most important regional market. Increased availability of innovative therapies, improved social insurance offices, and favorable reimbursement terms are all playing important roles in the region's business growth. Inclusion of expensive medications like Fabrazyme by health insurance plans, as well as favorable regulatory medicinal services arrangements, are also encouraging pharmaceutical companies to increase R&D activity in the field of rare diseases.

Competitive Players

Some main participants of the global Fabry disease treatment market are ISU Abxis Co Ltd., Greenovation Biotech GmbH, Amicus Therapeutics Inc., Avrobio Inc., Shire Plc., Sanofi S.A.,  Moderna Therapeutics Inc., JCR Pharmaceuticals, Protalix Biotherapeutics Inc., and Idorsia Pharmaceuticals Ltd., amongst others.

Fabry Disease Treatment Market: Regional Segment Analysis

• North America
  • U.S.
  • Canada
• Europe
  • UK
  • France
  • Germany
  • Italy
  • Spain
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • South Korea
  • Southeast Asia
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America
• Middle East and Africa
  • GCC Countries
  • South Africa
  • Rest of MEA